Use the JIT recompiler instead of JITIL, JITIL has been slower for a while and is still quite a bit slower than JIT despite the recent fixes/optimizations. Disable CPU -> EFB Access and Safe Texture Cache unless the game you are playing requires those options to be enabled. If you need to use the safe texture cache, fast or normal might be a better choice unless the safe option is required.
If you are playing in Windowed mode, I would recommend no more than 1024 x 768 resolution, 1280 x 1024 as the max but that seems to cause slowdowns with some games. Try a lower resolution, 1x EFB scale with 4x SSAA in the latest revisions any more than that and it's going to kill performance, at least it does for me with my Core2Duo E8500 and Geforce 9800 GT.
If you are playing in Windowed mode, I would recommend no more than 1024 x 768 resolution, 1280 x 1024 as the max but that seems to cause slowdowns with some games. Try a lower resolution, 1x EFB scale with 4x SSAA in the latest revisions any more than that and it's going to kill performance, at least it does for me with my Core2Duo E8500 and Geforce 9800 GT.