thanks, ill try that
EDIT: Unfortunately, the same behaviour here: First run works perfectly, afterwards, emulator will crash with the same game.
Mmmmmhhhh ... What files will the emulator change when running a game for the first time?
EDIT: Mmmmmhhh ... what files does the User folder contain when ...
>>>>>> I just run the emulator
User_justrun/Config/Dolphin.ini
User_justrun/Config/Logger.ini
User_justrun/Logs/dolphin.log
User_justrun/Wii/shared2/ec/shopsetu.log
User_justrun/Wii/shared2/succession/shop.log
User_justrun/Wii/shared2/sys/SYSCONF
User_justrun/Wii/shared2/wc24/mbox/Readme.txt
User_justrun/Wii/shared2/wc24/mbox/wc24recv.ctl
User_justrun/Wii/shared2/wc24/mbox/wc24recv.mbx
User_justrun/Wii/shared2/wc24/mbox/wc24send.ctl
User_justrun/Wii/shared2/wc24/mbox/wc24send.mbx
User_justrun/Wii/shared2/wc24/misc.bin
User_justrun/Wii/shared2/wc24/nwc24dl.bin
User_justrun/Wii/shared2/wc24/nwc24fl.bin
User_justrun/Wii/shared2/wc24/nwc24fls.bin
User_justrun/Wii/shared2/wc24/nwc24msg.cbk
User_justrun/Wii/shared2/wc24/nwc24msg.cfg
User_justrun/Wii/sys/uid.sys
>>>>>> I configure the controller
User_controllerconfig/Config/Dolphin.ini
User_controllerconfig/Config/GCPadNew.ini
User_controllerconfig/Config/Logger.ini
User_controllerconfig/Config/WiimoteNew.ini
User_controllerconfig/Logs/dolphin.log
User_controllerconfig/Wii/shared2/ec/shopsetu.log
User_controllerconfig/Wii/shared2/succession/shop.log
User_controllerconfig/Wii/shared2/sys/SYSCONF
User_controllerconfig/Wii/shared2/wc24/mbox/Readme.txt
User_controllerconfig/Wii/shared2/wc24/mbox/wc24recv.ctl
User_controllerconfig/Wii/shared2/wc24/mbox/wc24recv.mbx
User_controllerconfig/Wii/shared2/wc24/mbox/wc24send.ctl
User_controllerconfig/Wii/shared2/wc24/mbox/wc24send.mbx
User_controllerconfig/Wii/shared2/wc24/misc.bin
User_controllerconfig/Wii/shared2/wc24/nwc24dl.bin
User_controllerconfig/Wii/shared2/wc24/nwc24fl.bin
User_controllerconfig/Wii/shared2/wc24/nwc24fls.bin
User_controllerconfig/Wii/shared2/wc24/nwc24msg.cbk
User_controllerconfig/Wii/shared2/wc24/nwc24msg.cfg
User_controllerconfig/Wii/sys/uid.sys
>>>>>> I run super mario
User_supermario/Config/Dolphin.ini
User_supermario/GC/MemoryCardA.EUR.raw
User_supermario/GC/SRAM.raw
User_supermario/Logs/dolphin.log
User_supermario/ShaderCache/ogl-GMSP01-shaders.cache
User_supermario/Wii/shared2/ec/shopsetu.log
User_supermario/Wii/shared2/succession/shop.log
User_supermario/Wii/shared2/sys/SYSCONF
User_supermario/Wii/shared2/wc24/mbox/Readme.txt
User_supermario/Wii/shared2/wc24/mbox/wc24recv.ctl
User_supermario/Wii/shared2/wc24/mbox/wc24recv.mbx
User_supermario/Wii/shared2/wc24/mbox/wc24send.ctl
User_supermario/Wii/shared2/wc24/mbox/wc24send.mbx
User_supermario/Wii/shared2/wc24/misc.bin
User_supermario/Wii/shared2/wc24/nwc24dl.bin
User_supermario/Wii/shared2/wc24/nwc24fl.bin
User_supermario/Wii/shared2/wc24/nwc24fls.bin
User_supermario/Wii/shared2/wc24/nwc24msg.cbk
User_supermario/Wii/shared2/wc24/nwc24msg.cfg
User_supermario/Wii/sys/uid.sys
short story short: It was the shaders cache file. Once removed, the file will start again.
thank you, JMC47!