can you make disable destenation alpha pass more disabel
Nope, but what is your problem? Maybe it needs some other fix.
and can you make other renders like disable lights disable shadows somethings like that to make it faster i think that its a good idea
this would only turn of the graphical part and therefore wont help much.
the most stress is on the cpu and as long as you cant tell in the runtime which parts of ppc-asm will create shadows, its not possible.
Games have different ways of shadowing like using Stencil buffer or the crazy one in Mario Sunshine, where it does crazy alpha destination on these gray spheres representing parts of mario.