Dolphin, the GameCube and Wii emulator - Forums

The Simpsons: Hit and Run not running on OS X is a known issue. It's currently the only game I know of (off the top of my head) that has any OS-specific issues (not counting things that are broken on OpenGL and not on DX9/DX11), and I haven't a damn clue what could be causing it, since it went unaffected by the whole huge rewrite of the OpenGL backend that fixed Billy Hatcher and the Giant Egg not working on OS X.

I have actually found a solution but it doesn't run perfectly. You have to set the external frame buffer to virtual and it runs it. But it also screws up a bunch of other
games so thats what i use it for