(there might be SLIGHT spoilers in this)
I have been playing this game (now at 115h), near the end, pretty much everything done... but i just got a gamebreaking issue...
In Alcamoth, (post mechonis), as soon as I enter, the game slow down to about 10fps, even menu...
Using 3.5-1593... tried both HLE, LLE, changing many settings, dx9,11,opengl, checking and unchecking most options...
What is even weirder is that it USED to be fine... even recently... it suddently happened... i ran out, saved, reloaded, hoping it would fix itself... but it did not!!
I have a ATI HD 7880 with i7-3770 and 8gb ram... so no problem running full game at 30fps...
I use the PAL version with 30fps patch and HD texture pack.. tried disabling it as well, didnt fix it...
If anyone wants to try my save file... I dont want to start again after 115hours... I can still go finish the game at least... but would not be able to complete my "near-100% perfect run"...
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Here is a zip file of my save folder... 2 copy of the save are in slot 1 and 3... you can simply copy "monado1" over whichever you want to test...
EDIT : After 2 days of messing around, i finally found a solution... my guess is that this was due to a bug with the game more than with the emulator... i went back in alcamoth, killed one a few ennemies (ULTRA slow 10fps), then looted the chests... there were more than 1... after looting them all, speed came back full!! That is BY FAR the most weird bug i have ever seen in the last 30years of gaming!

-- I wanted to delete my own post but since i'm new i did not have permission...