Unable to interact with any loaded ROM's

[Shonumi]

You haven't said which games you're trying to play. If you're playing Wii games but have only setup the Gamecube controller, it won't work unless the real game supports GC controllers (e.g. SSBB, MK Wii). Other Wii games use the Wiimote; Dolphin emulates this too, just click the "Wiimote" button and then configure the input.