You can trade smoother (but slower) gameplay for faster (but no so smooth) gameplay by setting Frameskip to 1, it's the only thing that really works for me in this game and it's not that bad.
Rig
*Corei5 3570K *Nvidia 9800GT 1GB DDR3
*Motherboard Asus P8H77M-PRO *Win7 x64
*RAM 8GB DDR3(1600)
