If you're not using netplay then you're not getting the slowdown associated with netplay. You won't benefit from recompiling Dolphin with all of the netplay stuff commented out. It's a similar story for pretty much every other setting - if it's off, it's got no performance impact.
OS: Windows 10 64 bit Professional
CPU: AMD Ryzen 5900X
RAM: 16GB
GPU: Radeon Vega 56
CPU: AMD Ryzen 5900X
RAM: 16GB
GPU: Radeon Vega 56
