Setting for best graphical experience

[The Street is Almond]

Hello everyone! I bought a pc with the intention of running emulators to the max, my specs are a core i5 4690k, a gtx 970 and 8 gigs of ram, now there are a lot of graphical setting and some people say that you don't need to max everything because after some point there is no deference or you are wasting gpu power for no gain, so I would love if you guys could help me in tuning my setting to the max without overdoing them if you know what I mean, my screen is 1080P by the way.