Random slowdowns

[DefenderX]

Okay, first of all, set your IR to 2x, 1.5x or 1x (you have to try out, i don't know if your GPU can handle 2x). Besides, check "OpenMP Texture Decoder" and "Lock Threads to Cores". Also swtich your Backend to Direct3D9 and set EFB Copies to RAM.

And you can also try to enable the ZTP hack. Goto your game -> right click -> properties -> ZTP hack.

This should help ya.