RE(4) on the Wii definitely needs the Wiimote pointer to aim your gun, IIRC. Upside is you can find something like (http://www.amazon.com/Nextronics-Sensor-...B001UAAX60) and use it and it'll work fine
AMD Ryzen 7 3700X @ 4.2 GHz | MSI GTX 1070TI 8GB | 32 GB DDR4 @ 3000 MHz | Windows 10 Pro x64 | Dolphin 5.0-10886