Does running Dolphin in Admin mode solve your problem?
If yes, check your read/write permissions on the Dolphin Emulator folder in My Documents
If no, check the md5 sum of the game. You can right-click the game in Dolphin, go to Properties, and then the Info tab to compute the md5 sum. Then, compare that to a known good md5 of the game from a website like gameTDB.com
If yes, check your read/write permissions on the Dolphin Emulator folder in My Documents
If no, check the md5 sum of the game. You can right-click the game in Dolphin, go to Properties, and then the Info tab to compute the md5 sum. Then, compare that to a known good md5 of the game from a website like gameTDB.com

