It sounds like you have a problem with your configuration. I can't exactly help you beyond telling you to just wipe everything and try again; which I'm sure you've already tried. Your ISO is good, I don't see any broken/stupid settings, and MMU shit should definitely be off (it'll just make the game run slower.)
You could try reinstalling dependencies, maybe? Or testing the very latest builds, I don't know.
You could try reinstalling dependencies, maybe? Or testing the very latest builds, I don't know.