Keep Dolphin Portable?

[Runo]

Well when I unpack dolphin to my emulators folder and run it it asks me if I want to keep Dolphin portable, and I usually say yes, but now I heard that keeping softwares portable can affect their performance, does it make any difference? If yes, what do you guys usually do, is there any installer or just say no and place it on program files, what should make it more stable/fast?