I'm not sure how representative this scene is compared to the rest of the game, but the following video of a combat situation shows that Xenoblade works without issue with a recent development build of Dolphin on a Ryzen 2400G at 4GHz: https://youtu.be/ik3zLdM25E0?t=5m26s
Since you'll be using discrete graphics, the only fundamental difference would be that the Ryzen 2400G is a 4core/8thread part while the 2200G is 4core/4thread...but Dolphin only really cares about having two to three fast threads, so the 4 threads of the 2200G is already more than enough (you can see on the left-side chart in the video that half of the CPU threads have utilization in the single-digit range, implying that they're barely if at all being used by Dolphin).
Since you'll be using discrete graphics, the only fundamental difference would be that the Ryzen 2400G is a 4core/8thread part while the 2200G is 4core/4thread...but Dolphin only really cares about having two to three fast threads, so the 4 threads of the 2200G is already more than enough (you can see on the left-side chart in the video that half of the CPU threads have utilization in the single-digit range, implying that they're barely if at all being used by Dolphin).
Dolphin 5.0 CPU benchmark
CPU: Pentium G3258 @ 4.5GHz 1.24v
GPU: Intel integrated
RAM: 4x4GB Corsair Vengence @ DDR3-1600
OS: Linux Mint of some variety + [VM] Win7 SP1 x64
CPU: Pentium G3258 @ 4.5GHz 1.24v
GPU: Intel integrated
RAM: 4x4GB Corsair Vengence @ DDR3-1600
OS: Linux Mint of some variety + [VM] Win7 SP1 x64