How to play HD w/out affecting speed?

[los]

I've tried various internal resolution and anisotropic settings, but the only way to play a game like wind waker is with 1x native and a anisotropic setting of 2x. Is there a way I can play with 2x native and hopefully 16x anisotropic?

Dolphin 3.5.367
13'' macbook pro, Mac OS X Lion 10.7.5
2.3 GHz Intel Core i5
4 GB 1333 MHz DDR3
Intel HD Graphics 3000 384 MB