I bumped my clock up to 4.6ghz, and could run w/ no glitches on medium texture cache accuracy. This allowed some of the HUD items in Mario Galaxy to run correctly, however all of the world textures, and some of the HUD didn't load. When I go to safest accuracy all of the textures load, but there are still graphical hiccups and slowdown in FPS. I'll have to try some different games, perhaps Mario Galaxy is just one of the more demanding. I haven't done enough testing to know or not.
Windows 10 Pro 64-Bit | Core i5 4690K @ 4.3ghz | eVGA SC+ ACX 2.0 GTX 980 Ti (x2 Sli) | Noctua NH-D15 | 16GB DDR3-2400 ram | MSI Z97 Gaming 5 | 500 GB Samsung 850 EVO SSD
