FWIW, AMD cards tend to work better with the Direct3D backend.
Anyways, can you try deleting the Config folder in (Your user) > Documents > Dolphin Emulator?
I just want to rule out any configuration issues due to jumping versions which can sometimes happen.
Also, do you have the latest 64 bit VS2015 runtimes correctly installed as detailed on the download page?
https://www.microsoft.com/en-us/download/details.aspx?id=48145
Anyways, can you try deleting the Config folder in (Your user) > Documents > Dolphin Emulator?
I just want to rule out any configuration issues due to jumping versions which can sometimes happen.
Also, do you have the latest 64 bit VS2015 runtimes correctly installed as detailed on the download page?
https://www.microsoft.com/en-us/download/details.aspx?id=48145