If you have a strong enough PC, you basically don't have to worry about enabling any option. It's all relative. If you're running an i7-2600K at 4.2GHz, you don't have a lot to fear. On the other hand if you're me and you're running a low clocked AMD CPU, you'll probably want to use the settings that can still get the job done but not make the game unplayable. It all depends on the game and what kind of PC you have. Once you've been using Dolphin long enough you'll start to know which settings some games need and which options you can get away with not using at all. In the end it all comes down to if your PC is strong enough to use two main settings.
1) LLE audio vs. HLE audio: Use LLE and have the game sounds be almost as good as the console at the cost of needing a more powerful CPU, or use the HLE backend and have the game run faster but have inaccurate or missing sounds (although that's starting to not be the case with the current work delroth is doing with HLE).
2) EFB to Ram vs. EFB to Texture: That's basically the same story as the audio, only on the graphics end. Sometimes you can get away with using the less demanding option (EFB to Texture), other times you will need to use the accurate (EFB to Ram) option for the game to play properly.
Anyway, this is probably more information than you asked for, but I felt like typing it anyway.
1) LLE audio vs. HLE audio: Use LLE and have the game sounds be almost as good as the console at the cost of needing a more powerful CPU, or use the HLE backend and have the game run faster but have inaccurate or missing sounds (although that's starting to not be the case with the current work delroth is doing with HLE).
2) EFB to Ram vs. EFB to Texture: That's basically the same story as the audio, only on the graphics end. Sometimes you can get away with using the less demanding option (EFB to Texture), other times you will need to use the accurate (EFB to Ram) option for the game to play properly.
Anyway, this is probably more information than you asked for, but I felt like typing it anyway.
Asus Laptop: K53TA
OS: Windows 7 Home Premium, 64-Bit - SP1
CPU: AMD Llano A6-3400M, Quad-Core, 1.4GHz-2.6GHz (Overclocked)
GPU: AMD Radeon HD6650M, 1GB GDDR3 (Catalyst 13.1)
RAM: Samsung 4GB DDR3-1333
OS: Windows 7 Home Premium, 64-Bit - SP1
CPU: AMD Llano A6-3400M, Quad-Core, 1.4GHz-2.6GHz (Overclocked)
GPU: AMD Radeon HD6650M, 1GB GDDR3 (Catalyst 13.1)
RAM: Samsung 4GB DDR3-1333