(09-30-2015, 10:51 PM)Genesis Wrote: Are there any disadvantages on running games on gcz format rather than on iso format? Are there any difference at all besides saving HD space?
The only difference is that Dolphin uses a tiny bit more of your CPU. You're not going to notice anything. (There is an additional difference for Wii games, though.)
Compressing the game to GCZ isn't a proper fix for the bug, but it does make sense that it acts as a workaround that lets you play the game normally, so go for it!