The game runs fine for me on Dolphin SVN R4775 x64 IL version. It almost always runs at full speed and has sound. The intro and the title screen are messed. Some movies are also messed but after the movie the games goes on without a problem. The savegames function also works. See the screenshots and settings below.
Case: Gigabyte GZ-X1
PSU: FSP Aurum Gold 700W
Motherboard: Asus P8Z68-V LE
CPU: Intel Core i5-2500K
RAM: Kingston 8 GB HyperX PnP DDR3 1600MHz CL9 KIT
VGA: ASUS GeForce GTX 560 DirectCu II TOP
OS: Windows 7 Professional x64
PSU: FSP Aurum Gold 700W
Motherboard: Asus P8Z68-V LE
CPU: Intel Core i5-2500K
RAM: Kingston 8 GB HyperX PnP DDR3 1600MHz CL9 KIT
VGA: ASUS GeForce GTX 560 DirectCu II TOP
OS: Windows 7 Professional x64