The Simpsons: Hit and Run not running on OS X is a known issue. It's currently the only game I know of (off the top of my head) that has any OS-specific issues (not counting things that are broken on OpenGL and not on DX9/DX11), and I haven't a damn clue what could be causing it, since it went unaffected by the whole huge rewrite of the OpenGL backend that fixed Billy Hatcher and the Giant Egg not working on OS X.
<@skid_au> fishing resort is still broken: http://i.imgur.com/dvPiQKg.png
<@neobrain> dafuq
<+JMC47> no dude, you're just holding the postcard upside down
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<@Lioncash> pauldachz in charge of shitposting :^)
<@neobrain> dafuq
<+JMC47> no dude, you're just holding the postcard upside down
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<@Lioncash> pauldachz in charge of shitposting :^)