I'd surely be much better to have an ini file with two profiles just for the few games it matters, e.g. EFB->RAM for Super Mario Bros for the spinning coins and LLE for Zelda microcode games. Most things will just be slowed down with more accurate settings for basically no reason, and it's a hell of a lot of work to redo all the games.
OS: Windows 10 64 bit Professional
CPU: AMD Ryzen 5900X
RAM: 48GB
GPU: Radeon 7800 XT
CPU: AMD Ryzen 5900X
RAM: 48GB
GPU: Radeon 7800 XT