To my knowledge it doesn't. You will get a wiimote out of sync error unless you have panic handler enabled, and it seems to state the only solution is to restart the emulator. In SSBB, if played with GC controller, you'll get this message after 5 minutes, however you can still play.
Specs: intel i5 3570k @ 3.4GHz;
16Gb RAM; Raedon HD 7900;
Win8 64-Bit
16Gb RAM; Raedon HD 7900;
Win8 64-Bit
