You need a faster processor, overclock if you can. Frameskip won't help in most cases, and OpenMP doesn't provide significant speedups (in some cases it'll just slow down a bit)... I can't say anything about Metroid Prime (I don't have that game), but at least for Twilight Princess, If you want to sacrifice accuracy for some small speed ups, you can change EFB Copies to Texture, however doing so will leave the minimap completely bugged. Keep in mind that TP forces EFB to RAM in their game INI, so, an easy way to override the enforcement would be opening your graphics config window while TP is running and setting EFB to Texture...
Avell A70 MOB: Core i7-11800H, GeForce RTX 3060, 16 GB DDR4-3200, Windows 11 (Insider Preview)
ASRock Z97M OC Formula: Pentium G3258, GeForce GT 440, 16 GB DDR3-1600, Windows 10 (22H2)
ASRock Z97M OC Formula: Pentium G3258, GeForce GT 440, 16 GB DDR3-1600, Windows 10 (22H2)