Your PC should be able to run quite a few games without serious issues. I'd just start with the default settings and tweak from there, with the biggest slow features being Store EFB Copies to RAM and the Store XFB Copies to RAM (or RealXFB in older builds.)
There are some games that'll be a bit too strenuous to maintain full speed at all times, but, it shouldn't be all that common among the popular games.
There are some games that'll be a bit too strenuous to maintain full speed at all times, but, it shouldn't be all that common among the popular games.