@OP: Ge the latest dev. version of Dolphin from the Downloads page, extract it in a new folder and run it in portable mode (create an empty portable.txt file). Leave all graphics settings at default. Just disable VSync and set the speed to 'Unlimited'. Run the title that's lagging for you and check the FPS counter. Then open the graphics settings while it's running and untick the option 'Enable CPU->EFB Access'. Check the FPS counter again. Do you see a HUGE increase in FPS?
Then try Ishiiruka with all the tips from the previous posts (also running in portable mode).
See if it makes any difference.
Then try Ishiiruka with all the tips from the previous posts (also running in portable mode).
See if it makes any difference.